Food intake regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta

Food intake regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta

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Abstract Background Neuropeptide Y (NPY), agouti related peptide (AgRP), copyright and amphetamine-regulated transcript (CART) and melanocortins, the products of the proopiomelanocortin (POMC), are hypothalamic peptides involved in feeding regulation and energy homeostasis.Recent evidence has demonstrated their expression in rat and human placenta.Methods In the current study, we tsc apparel houston have investigated the expression of those neuropeptides in the rat placenta by real-time PCR using a model of maternal food restriction.Results Our results showed that placental-derived neuropeptides were regulated through pregnancy and following food restriction.

Conclusion These data could red prairie spy apple indicate that placental-derived neuropeptides represent a local regulatory circuit that may fine-tune control of energy balance during pregnancy.